The ultimate goal of periodontal therapy is to restore the periodontal health by complete regeneration of the attachment apparatus. Though numerous methods of regeneration are available, researches are directed towards search for autologous materials considering the safety and availability issues. Among the various autologous material options, use of platelet concentrates have found to be more promising due to ease of procurement, handling and biochemical properties. This article throws limelight on the role of platelets on wound healing, preparation, mechanical properties, biochemical properties and clinical application of PRF in periodontal regeneration.
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