Root canal therapy for the management of pulpo-periapical diseases involves three phases access to the pulp space, removal of the necrotic content from the canals and obturating the space with synthetic biomaterials. Majority of the failures in root therapy is attributed to the last phase of obturation. Persistence of infection or reinfection is mainly due to the re-establishment of the microbes in the canal space establishing through the interface between the natural root dentin and the artificial sealers and obturating materials. Thus the focus started on filling the space with the natural pulp and dentin structures in the root canal without resorting to synthetic materials. Thus emerged the concept of Pulpal Regeneration. Revascularization of the pulp, use of stem cell engineering are few concepts in this. This article focuses on the current tend and practice of pulpal regeneration and the biomaterials that are used for regeneration and tissue engineerings.
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