Danio Rerio (Zebrafish): A Cost Effective Animal Model for Anti-Tuberculosis Drug Research.
MI Glad Mohesh, B Narasimha Rao
Keywords :
Antituberculosis, Drug discovery, Zebrafish, Animal model
Citation Information :
Mohesh MG, Rao BN. Danio Rerio (Zebrafish): A Cost Effective Animal Model for Anti-Tuberculosis Drug Research.. 2015; 4 (2):29-32.
Animal models help us to understand and explore disease mechanisms. Every disease causing organism has its own evolving genome and interacting ways with the environment, which demands new animal models for studying them. Versatile and cost effective disease models are always in demand for drug discovery. Laboratory mouse and rat animal models, though well appreciated in the fields of drug discovery and basic science research is getting replaced with the disease models of Zebrafish as they are easy to breed, hold and discard. Cost effectiveness and the less implied Animal ethics regulations have made researchers in the West to shift to this model. Although Zebrafish models on various diseases are available, tuberculosis disease model is discussed here for the benefit of researchers interested or involved in anti-tuberculosis drug discovery.
Tuberculosis control in the South-East Region. Annual TB report 2015.WHO. pgs 5-99.
http://zfin.org/zf_info/zfbook/zfbk.html.
Thomas A Rando. Of fish and men. Nature chemical biology. 2014; 10: 91-92.
Donglai Shenget al. Deletion of the WD40 Domain of LRRK2 in Zebrafish Causes Parkinsonism -Like Loss of Neurons and Locomotive Defect. PLoS Genetics, 2010; 6 (4): e1000914 DOI: 10.1371/journal.pgen.1000914.
Zebrafish as a new model organism for Parkinson's disease. Rob Willem sen, Wiebren Hasselaar, Herma van der Linde, Vincenzo Bonifati. Proceedings of Measuring Behavior. 2008; 50-51.
Panula, P., et al. (2006) Modulatory Neurotransmitter Systems and Behavior: Towards Zebra fish Models of Neurodegenerative Diseases. Zebrafish 2006; 3(2): 235-47.
Y. Ito, A. Kato, T. Hirata, S. Hirose, M. F. Romero. Na/H and Na/NH4-exchange activities of Zebrafish NHE3b expressed in Xenopus oocytes. AJP: Regulatory, Integrative and Comparative Physiology, 2014; DOI: 10.1152/ajpregu.00363.2013.
Julien Ablain1 and Leonard I. Zon. Of fish and men: using Zebrafish to fight human diseases. Trends in Cell Biology December 2013;23(12):584-586.
Howe, K. et al. The Zebrafish reference genome sequence and its relationship to the human genome. Nature 2013; 496, 498-503.
Bruno, D.W., J. Griffiths, C.G. Mitchell, B.P. Wood, Z.J. Fletcher, F.A. Drobniewski, T.S. Hastings. “Pathology attributed to Mycobacterium chelonae infection among farmed and laboratory-infected Atlantic salmon Salmo salar”. Diseases of Aquatic Organisms. 1998;33: 101-109.
Stamm, Luisa M et al. “Mycobacterium marinum escapes from phagosomes and is propelled by actin-based motility”. JEM. 2003; 198: 1361-1368.
L. Ramakrishnan, Images in clinical medicine. Mycobacterium marinum infection of the hand, N. Engl. J. Med. 1997; 337:612.
Jonnalagadda Padma Sridevi, Hasitha Shilpa Anantaraju, Pushkar Kulkarni, Perumal Y, Dharmarajan Sriram. Optimization and validation of Mycobacterium marinum-induced adult Zebrafish model for evaluation of oral anti-tuberculosis drugs. International Journal of Mycobacteriology. 2014;3:259-267.
