Animal models help us to understand and explore disease mechanisms. Every disease causing organism has its own evolving genome and interacting ways with the environment, which demands new animal models for studying them. Versatile and cost effective disease models are always in demand for drug discovery. Laboratory mouse and rat animal models, though well appreciated in the fields of drug discovery and basic science research is getting replaced with the disease models of Zebrafish as they are easy to breed, hold and discard. Cost effectiveness and the less implied Animal ethics regulations have made researchers in the West to shift to this model. Although Zebrafish models on various diseases are available, tuberculosis disease model is discussed here for the benefit of researchers interested or involved in anti-tuberculosis drug discovery.
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