microRNAs, small non-coding RNAs, have recently emerged as powerful regulators in a variety of cellular processes especially important roles in disease and tissue remodeling. Apart from involvement in a variety of biological processes, microRNAs were early recognized for their potential use as biomarkers in disease diagnostics and prognosis. Currently, there are number of microRNAs helping clinicians to determine the origins of cancer in disseminated tumors. The development of microRNA therapeutics has proved more challenging mainly due to delivery issues. This review focuses on the potential role of as clinical diagnostic and prognostic biomarkers. In addition, it highlights the microRNA profiling techniques, thereby leading to the advance opportunities to safely pursue microRNA as therapeutic modalities.
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