Annals of SBV

Register      Login

VOLUME 5 , ISSUE 1 ( Jan-Jun, 2016 ) > List of Articles

Post-mortem examination- combining conventional autopsy techniques with virtual autopsyconcerted efforts by the departments of forensic medicine and toxicology and radiology.

Dipayan Deb Barman, G Vijaya Kumar Nair

Keywords : Hypoxia, Macrophage infiltration, Obesity,Adipose tissue

Citation Information : Barman DD, Nair GV. Post-mortem examination- combining conventional autopsy techniques with virtual autopsyconcerted efforts by the departments of forensic medicine and toxicology and radiology.. 2016; 5 (1):77-79.

DOI: 10.5005/jp-journals-10085-5116

License: CC BY-NC 4.0

Published Online: 00-06-2016

Copyright Statement:  Copyright © 2016; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Obesity is linked to a variety of metabolic disorders, such as insulin resistance and atherosclerosis. The increased incidence of obesity has led to rise in interest in the biology of white adipose tissue (WAT). The tissue is no longer considered as a passive fat storage tissue but is a key endocrine and signaling organ secreting a multiplicity of protein factors called adipokines. In obesity, there is an enhanced secretion of a number of adipokines underpinning the role of inflammation in white adipose tissue towards the development of obesity and associated diseases. There is a substantial evidence, particularly from animal studies, that hypoxia develops in adipose tissue as the tissue mass expands in obesity, and the reduction in PO2 is considered to underlie the inflammatory response. The cells present within the WAT respond to hypoxia, by inhibiting the differentiation of pre-adipocytes to adipocytes and instead being transformed into leptin-secreting cells. The dynamic change found in the adipose tissue can be referred to as “adipose tissue remodeling,” in which stromal cells change dramatically in number and type during the course of obesity. Among stromal cells, infiltration of macrophages in the adipose tissue precedes the development of insulin resistance in animal models, suggesting that they are responsible for obesity-related adipose tissue inflammation. Understanding the molecular mechanism underlying adipose tissue remodeling may lead to the identification of novel, therapeutic strategies to prevent obesity-induced adipose tissue inflammation.


PDF Share
  1. The future is Virtopsy: Sequence format (Neue Zuricher Zeitung) Telecast, 2006, www.Virtopsy.com (accessed on 20 May 2016)
  2. Thali MJ, Yen K, Vock P, Ozdoba C, Kneubuehl BP, et al. Image-guided virtual autopsy findings of gunshot victims performed with multi-slice computed tomography and magnetic resonance imaging and subsequent correlation between radiology and autopsy findings. Forensic Sci Int. 2003;138:8-16
  3. Thali MJ, Braun M, Buck U, Aghayev E, Jackowski C, et al. VIRTOPSY—scientific documentation, reconstruction and animation in forensic: individual and real 3D data based geometric approach including optical body/object surface and radiological CT/MRI scanning. J Forensic Sci. 2005; 50:428-42
  4. Dirnhofer R, Jackowski C, Vock P, Potter K, Thali MJ. VIRTOPSY: minimally invasive, imaging-guided virtual autopsy. Radiographics. 2006; 26:1305-33.
  5. Buck U, Naether S, Braun M, Bolliger S, Friederich H, et al. Application of 3D documentation and geometric reconstruction methods in traffic accident analysis: with high resolution surface scanning, radiological MSCT/MRI scanning and real data based animation. Forensic Sci Int. 2007;170:20-8.
  6. Thali MJ, Barun M, Dirnhofer R. Optical 3D surface digitizing in forensic medicine: 3D documentation of skin and bone injuries. Forensic Sci Int. 2003:137:203-8.
  7. Plattner T, Thali MJ, Yen K, Sonnenschein M, Stoupis C, et al. Virtopsy-postmortem multislice computed tomography (MSCT) and magnetic resonance imaging (MRI) in a fatal scuba diving incident. J Forensic Sci. 2003; 48:1347- 55.
  8. Takatsu A, Suzuki N, Hattori A, Shigeta A. The concept of the digital morgue as a 3D database. Leg Med (Tokyo). 1999;1:29-33.
  9. McHaffie HE, Fowlie PW, Hume R, Laing IA, Lloyd DJ, et al. Consent to autopsy for neonates. Arch Dis Child Fetal Neonatal Ed. 2001;85:F4-F7.
  10. Breeze ACG, Statham H, Hackett GA, Jessop FA, Lees CC. Perinatal postmortems: what is important to parents and how do they decide? Birth. 2012;39:57-64.
  11. Maldonado MT. Psicologia da gravidez. 17a ed. São Paulo: Saraiva; 2009
  12. Junior R, Souza P, Coudyzer W, Thevissen P, Willems G, et al. Virtual autopsy in forensic sciences and its applications in the forensic odontology. Rev Odonto Cienc. 2012; 27:5-9.
  13. Rüegger CM, Bartsch C, Martinez RM, Ross S, Bolliger SA et al. Minimally invasive, imaging guided virtual autopsy compared to conventional autopsy in foetal, newborn and infant cases: study protocol for the paediatric virtual autopsy trial. Paediatrics 2014, 14:15
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.