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VOLUME 7 , ISSUE 1 ( Jan-Jun, 2018 ) > List of Articles
Citation Information : Ilanchezhian T. F - 05: Comparative Study of the Estimation of Ldl Cholesterol by the Direct Method and Friedewald Equation in Secondary Hyperlipidemia. 2018; 7 (1):93-93.
License: CC BY-NC 4.0
Published Online: 03-08-2020
Copyright Statement: Copyright © 2018; The Author(s).
Aim & Objective: The objective of the study is to measure the difference between the levels of LDL by Direct method versus Friedewald equation. Methodology: The study includes 30 patients and 30 controls in the age of 25 - 75 years of both sexes. Fasting blood samples were collected and estimated Total Cholesterol (TC), Triglycerides (TG), Low Density Lipoprotein (LDL-C) cholesterol and High density lipoprotein (HDL) cholesterol, LDL cholesterol by direct method and by Friedewald's formula (FW). Result: There is a significant difference between LDL Direct and LDL-FW at triglyceride range of 1 - 100, (p= 0.01), 201 - 300 (p= 0.01) and no significant difference (p= 0.9) at 101 - 200, (p= 0.3) at 301 - 400 and (p= 0.2) at > 400. There is a significant difference between LDL Direct and LDL-FW (p= 0.01) at total cholesterol range of 200 - 249 and no significant difference (p= 1.0) at 100 - 149, (p= 1.0) at 150 - 199 and (p= 0.9) at > 250. There is significant difference between LDL values by direct and FW method (p=0.0490). LDL by Direct method is lower due to non interference of cholesterol and triglyceride, and LDL by FW is higher due to interference by cholesterol and triglyceride. Conculsion: The study has concluded that LDL-Cholesterol by Direct method is reliable than Friedewald equation.