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VOLUME 8 , ISSUE 2 ( July-December, 2019 ) > List of Articles

REVIEW ARTICLE

Soft Tissue Sarcomas: An Overview on Histomorphology

Shameera Begum, Shanmugasamy Kathirvelu, Anandraj Vaithy

Keywords : Histomorphology, Malignant soft tissue tumors, Sarcomas,Classification of soft tissue sarcomas

Citation Information : Begum S, Kathirvelu S, Vaithy A. Soft Tissue Sarcomas: An Overview on Histomorphology. 2019; 8 (2):45-50.

DOI: 10.5005/jp-journals-10085-8114

License: CC BY-NC 4.0

Published Online: 00-12-2019

Copyright Statement:  Copyright © 2019; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Background: Soft tissue sarcomas (STS) comprise a diverse group of rare malignancies that arise from connective tissues. The natural course of STS is unpredictable and aggressive if not diagnosed at an early stage. Discussion: The subclassification of these tumors is important for prognosis and clinical management of patients. In the present review, we discuss the histomorphologic features of STS and its subtypes based on 2013 World Health Organization classification and throw light on the incidence and presentation of STS. Conclusion: The systematic approach to morphologic assessment of STS outlined in this review will lead to narrowing of differential diagnoses and pave way for effective diagnosis and implementation of treatment strategies.


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  1. Hoang NT, Acevedo LA, Mann MJ, Tolani B. A review of soft-tissue sarcomas: translation of biological advances into treatment measures. Cancer Manag Res 2018;10:1089–1114. DOI: 10.2147/CMAR.S159641.
  2. Grimer R, Judson I, Peake D, Seddon B. Guidelines for the management of soft tissue sarcomas. Sarcoma 2010;2010:506182. DOI: 10.1155/2010/506182.
  3. van Vliet M, Kliffen M, Krestin GP, van Dijke CF. Soft tissue sarcomas at a glance: clinical, histological, and MR imaging features of malignant extremity soft tissue tumors. Eur Radiol 2009;19(6):1499–1511. DOI: 10.1007/s00330-008-1292-3.
  4. Fletcher CDM, Bridge JA, Hogendoorn PCW, Mertens F, ed. WHO Classification of Soft Tissue and Bone Tumors. 4th ed., Geneva, Switzerland: WHO Press; 2013.
  5. Doyle LA. Sarcoma classification: An update based on the 2013 World Health Organization Classification of Tumors of Soft Tissue and Bone: WHO Update of Sarcoma Classification. Cancer 2014;120(12):1763–1774. DOI: 10.1002/cncr.28657.
  6. World Health Organisation Classification of Tumours. In: Fletcher CDM, Unni KK, Mertens F, ed. Pathology and Genetics of Tumours of Soft Tissue. Lyon: IARC Press; 2002. pp. 12–224.
  7. Augsburger D, Nelson PJ, Kalinski T, Udelnow A, Knösel T, Hofstetter M, et al. Current diagnostics and treatment of fibrosarcoma –perspectives for future therapeutic targets and strategies. Oncotarget 2017;8(61):104638–104653. DOI: 10.18632/oncotarget.20136.
  8. Castronovo C, Arrese JE, Quatresooz P, Nikkels AF. Myxofibrosarcoma: A Diagnostic Pitfall. Rare Tumors 2013;5(2):60–61. DOI: 10.4081/rt.2013.e15.
  9. Oda Y, Takahira T, Kawaguchi K, Yamamoto H, Tamiya S, Matsuda S, et al. Low-grade fibromyxoid sarcoma versus low-grade myxofibrosarcoma in the extremities and trunk. A comparison of clinicopathological and immunohistochemical features. Histopathology 2004;45(1):29–38. DOI: 10.1111/j.1365-2559.2004.01886.x.
  10. Antonescu CR, Rosenblum MK, Pereira P, Nascimento AG, Woodruff JM. Sclerosing epithelioid fibrosarcoma: a study of 16 cases and confirmation of a clinicopathologically distinct tumor. Am J Surg Pathol 2001;25(6):699–709. DOI: 10.1097/00000478-200106000-00001.
  11. Akerman M. Malignant fibrous histiocytoma--the commonest soft tissue sarcoma or a nonexistent entity? Acta Orthop Scand Suppl 1997;273:41–46. DOI: 10.1080/17453674.1997.11744701.
  12. Gazziola C, Cordani N, Wasserman B, Carta S, Colombatti A, Perris R. Malignant fibrous histiocytoma: a proposed cellular origin and identification of its characterizing gene transcripts. Int J Oncol 2003;23(2):343–351. DOI: 10.3892/ijo.23.2.343.
  13. Paal E, Miettinen M. Retroperitoneal leiomyomas: a clinicopathologic and immunohistochemical study of 56 cases with a comparison to retroperitoneal leiomyosarcomas. Am J Surg Pathol 2001;25(11):1355–1363. DOI: 10.1097/00000478-200111000-00002.
  14. Rajani B, Smith TA, Reith JD, Goldblum JR. Retroperitoneal leiomyosarcomas unassociated with the gastrointestinal tract: a clinicopathologic analysis of 17 cases. Mod Pathol 1999;12(1):21–28.
  15. Enterline HT, Horn RC. Alveolar rhabdomyosarcoma. A distinctive tumor type. Am J Clin Pathol 1958;29(4):356–366. DOI: 10.1093/ajcp/29.4.356.
  16. Furlong MA, Mentzel T, Fanburg-Smith JC. Pleomorphic rhabdomyosarcoma in adults: a clinicopathologic study of 38 cases with emphasis on morphologic variants and recent skeletal muscle-specific markers. Mod Pathol 2001;14(6):595–603. DOI: 10.1038/modpathol.3880357.
  17. Smith MH, Atherton D, Reith JD, Islam NM, Bhattacharyya I, Cohen DM. Rhabdomyosarcoma, spindle cell/sclerosing variant: a clinical and histopathological examination of this rare variant with three new cases from the oral cavity. Head Neck Pathol 2017;11(4):494–500. DOI: 10.1007/s12105-017-0818-x.
  18. Hart J, Mandavilli S. Epithelioid angiosarcoma: a brief diagnostic review and differential diagnosis. Arch Pathol Lab Med 2011;135(2):268–272. DOI: 10.1043/1543-2165-135.2.268.
  19. Rekhi B, Ingle A, Kumar R, DeSouza MA, Dikshit R, Jambhekar NA. Malignant peripheral nerve sheath tumors: clinicopathological profile of 63 cases diagnosed at a tertiary cancer referral center in Mumbai, India. Indian J Pathol Microbiol 2010;53(4):611–618. DOI: 10.4103/0377-4929.71998.
  20. Rekhi B, Jambhekar NA. Malignant transformation in a hybrid schwannoma/perineurioma: addition to the spectrum of a malignant peripheral nerve sheath tumor. Indian J Pathol Microbiol 2011;54(4):825–828. DOI: 10.4103/0377-4929.91542.
  21. Jo VY, Fletcher CDM. Epithelioid malignant peripheral nerve sheath tumor: clinicopathologic analysis of 63 cases. Am J Surg Pathol 2015;39(5):673–682. DOI: 10.1097/PAS.0000000000000379.
  22. Tripathy K, Mallik R, Mishra A, Misra D, Rout N, Nayak P, et al. A rare malignant triton tumor. Case Rep Neurol 2010;2(2):69–73. DOI: 10.1159/000315621.
  23. Li G, Liu C, Liu Y, Xu F, Su Z, Wang Y, et al. Analysis of clinical features and prognosis of malignant triton tumor: a report of two cases and literature review. Oncol Lett 2015;10(6):3551–3556. DOI: 10.3892/ol.2015.3762.
  24. Gupta N, Sanchety N, Verma PS, Verma G. Malignant granular cell tumor of the breast; literature review. Indian J Pathol Microbiol 2015;58(2):238. DOI: 10.4103/0377-4929.155330.
  25. Dantonello TM, Leuschner I, Vokuhl C, Gfroerer S, Schuck A, Kube S, et al. Malignant ectomesenchymoma in children and adolescents: report from the Cooperative Weichteilsarkom Studiengruppe (CWS). Pediatr Blood Cancer 2013;60(2):224–229. DOI: 10.1002/pbc.24174.
  26. Kransdorf MJ. Malignant soft-tissue tumors in a large referral population: distribution of diagnoses by age, sex, and location. AJR Am J Roentgenol 1995;164(1):129–134. DOI: 10.2214/ajr.164.1.7998525.
  27. Stacchiotti S, Van Tine BA. Synovial sarcoma: current concepts and future perspectives. J Clin Oncol 2018;36(2):180–187. DOI: 10.1200/JCO.2017.75.1941.
  28. Fisher C, Folpe AL, Hashimoto H, Weiss SW. Intra-abdominal synovial sarcoma: a clinicopathological study. Histopathology 2004;45(3):245–253. DOI: 10.1111/j.1365-2559.2004.01950.x.
  29. Mohaidat ZM, Saleh A-AA, Al-Gharaibeh S, Yousef IR. Case report: synovial sarcoma of the axilla with brachial plexus involvement. World J Surg Oncol 2018;16(1):166. DOI: 10.1186/s12957-018- 1466-7.
  30. Armah HB, Parwani AV. Epithelioid sarcoma. Arch Pathol Lab Med 2009;133(5):814–819. DOI: 10.1043/1543-2165-133.5.814.
  31. Folpe AL, Deyrup AT. Alveolar soft-part sarcoma: a review and update. J Clin Pathol 2006;59(11):1127–1132. DOI: 10.1136/jcp.2005. 031120.
  32. Ananthamurthy A, Nisheena R, Rao B, Correa M. Extraskeletal myxoid chondrosarcoma: diagnosis of a rare soft tissue tumor based on fine needle aspiration cytology. J Cytol 2009;26(1):36–38. DOI: 10.4103/0970-9371.54867.
  33. Applebaum MA, Worch J, Matthay KK, Goldsby R, Neuhaus J, West DC, et al. Clinical features and outcomes in patients with extraskeletal Ewing sarcoma. Cancer 2011;117(13):3027–3032. DOI: 10.1002/cncr.25840.
  34. Shukla S, Singh SK, Pujani M. Multicentric malignant gastrointestinal stromal tumor. Saudi J Gastroenterol 2009;15(1):45–48. DOI: 10.4103/1319-3767.45055.
  35. Coindre J-M. Grading of soft tissue sarcomas: review and update. Arch Pathol Lab Med 2006;130(10):1448–1453. DOI: 10.1043/1543-2165(2006)130[1448:GOSTSR]2.0.CO;2.
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