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VOLUME 9 , ISSUE 1 ( January-June, 2020 ) > List of Articles

REVIEW ARTICLE

Expression of Hormone Receptor Status and HER-2/neu in Breast Cancers: A Review in Various Ethnic Groups

Nirmal Daniel, Mangala Goneppanavar, Sowmya Srinivasan

Citation Information : Daniel N, Goneppanavar M, Srinivasan S. Expression of Hormone Receptor Status and HER-2/neu in Breast Cancers: A Review in Various Ethnic Groups. 2020; 9 (1):12-16.

DOI: 10.5005/jp-journals-10085-8116

License: CC BY-NC 4.0

Published Online: 17-10-2020

Copyright Statement:  Copyright © 2020; The Author(s).


Abstract

The role of hormone receptor status including estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor type 2 (HER-2/neu) commonly termed as ER, PR, and HER-2/neu expression in breast cancer by immunohistochemistry (IHC) is a widely accepted tool to assess prognosis as well as therapeutic management. With further standardization of the reporting template prescribed by the College of American Pathologists as “CAP Protocol” and American Society of Clinical Oncology (“ASCO guidelines”), IHC has effectively replaced cytological assays in evaluating the status of expression of hormonal receptors. The pattern of these hormonal receptors’ expressions varies with regard to genetic, environment, lifestyle, and sociodemographic factors. There are well-established clinical evidences to substantiate the clinical utility of ER expression as a standard predictive biomarker to assess the prognosis of hormonal therapy. The same insight about the clinical utility of PR is questionable. However, the diagnostic utility of PR for predicting the clinical response to chemotherapy among ER-positive breast cancer patients remains unclear. This warrants future studies incorporating the integrated analysis of survival data, gene expression and its data profile, and compilation of ER and PR expressions from various large cohort analysis of breast cancer patients. This review focuses on the clinical utility and the inherent variation of the hormone receptor expression among notable diverse demographic study groups across the world.

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  1. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 2015;136(5):E359–E386. DOI: 10.1002/ijc.29210.
  2. Malvia S, Bagadi SA, Dubey US, Saxena S. Epidemiology of breast cancer in Indian women. Asia Pac J Clin Oncol 2017;13(4):289–295. DOI: 10.1111/ajco.12661.
  3. Gupta A, Shridhar K, Dhillon PK. A review of breast cancer awareness among women in India: cancer literate or awareness deficit? Eur J Cancer Oxf Engl 1990 2015;51(14):2058–2066. DOI: 10.1016/j.ejca.2015.07.008.
  4. Leong AS-Y, Zhuang Z. The changing role of pathology in breast cancer diagnosis and treatment. Pathobiology 2011;78(2):99–114. DOI: 10.1159/000292644.
  5. Hammond MEH, Hayes DF, Dowsett M, Allred DC, Hagerty KL, Badve S, et al. American Society of Clinical Oncology/college of American Pathologists Guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer (unabridged version). Arch Pathol Lab Med 2010 Jul;134(7):e48–e72. DOI: 10.1200/JCO.2009.25.6529.
  6. Jensen EV, Jordan VC. The estrogen receptor: a model for molecular medicine. Clin Cancer Res Off J Am Assoc Cancer Res 2003;9(6): 1980–1989.
  7. Barnes DM, Hanby AM. Oestrogen and progesterone receptors in breast cancer: past, present and future. Histopathology 2001;38(3):271–274. DOI: 10.1046/j.1365-2559.2001.01060.x.
  8. Zafrani B, Aubriot MH, Mouret E, de Cremoux P, De Rycke Y, Nicolas A, et al. High sensitivity and specificity of immunohistochemistry for the detection of hormone receptors in breast carcinoma: comparison with biochemical determination in a prospective study of 793 cases. Histopathology 2000;37(6):536–545. DOI: 10.1046/j.1365-2559.2000.01006.x.
  9. Colleoni M. Chemotherapy is more effective in patients with breast cancer not expressing steroid hormone receptors: a study of preoperative treatment. Clin Cancer Res 2004;10(19):6622–6628. DOI: 10.1158/1078-0432.CCR-04-0380.
  10. Qureshi A, Pervez S. Allred scoring for ER reporting and it's impact in clearly distinguishing ER negative from ER positive breast cancers. JPMA J Pak Med Assoc 2010;60(5):350–353.
  11. Iqbal N, Iqbal N. Human epidermal growth factor receptor 2 (HER2) in cancers: overexpression and therapeutic implications. Mol Biol Int 2014;2014:1–9. DOI: 10.1155/2014/852748.
  12. Verma S, Lavasani S, Mackey J, Pritchard K, Clemons M, Dent S, et al. Optimizing the management of her2-positive early breast cancer: the clinical reality. Curr Oncol 2010;17(4):20–33. DOI: 10.3747/co.v17i4.700.
  13. Wolff AC, Hammond MEH, Allison KH, Harvey BE, Mangu PB, Bartlett JMS, et al. Human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology/College of American Pathologists Clinical Practice Guideline focused update. Arch Pathol Lab Med 2018;142(11):1364–1382. DOI: 10.5858/arpa.2018-0902-SA.
  14. Han G. ER, PR and HER2 testing in breast cancer. Diagn Histopathol 2014;20(11):440–445. DOI: 10.1016/j.mpdhp.2014.10.002.
  15. Hammond MEH, Hayes DF, Dowsett M, Allred DC, Hagerty KL, Badve S, et al. American society of clinical oncology/college of american Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer. J Clin Oncol 2010;28(16):2784–2795. DOI: 10.1200/JCO.2009.25.6529.
  16. Tsang JYS, Tse GM. Molecular classification of breast cancer. Adv Anat Pathol 2019. 1.
  17. Russnes HG, Lingjærde OC, Børresen-Dale A-L, Caldas C. Breast cancer molecular stratification: from intrinsic subtypes to integrative clusters. Am J Pathol 2017;187(10):2152–2162. DOI: 10.1016/j.ajpath.2017.04.022.
  18. Mudduwa LKB. Quick score of hormone receptor status of breast carcinoma: Correlation with the other clinicopathological prognostic parameters. Indian J Pathol Microbiol 2009;52(2):159–163. DOI: 10.4103/0377-4929.48906.
  19. Viale G, Regan MM, Maiorano E, Mastropasqua MG, Dell'Orto P, Rasmussen BB, et al. Prognostic and predictive value of centrally reviewed expression of estrogen and progesterone receptors in a randomized trial comparing letrozole and tamoxifen adjuvant therapy for postmenopausal early breast cancer: BIG 1-98. J Clin Oncol Off J Am Soc Clin Oncol 2007;25(25):3846–3852. DOI: 10.1200/JCO.2007.11.9453.
  20. Desai SB, Moonim MT, Gill AK, Punia RS, Naresh KN, Chinoy RF. Hormone receptor status of breast cancer in India: a study of 798 tumours. The Breast 2000;9(5):267–270. DOI: 10.1054/brst.2000.0134.
  21. Redkar AA, Kabre SS, Mittra I. Estrogen & progesterone receptors measurement in breast cancer with enzyme-immunoassay & correlation with other prognostic factors. Indian J Med Res 1992;96: 1–8.
  22. Kaul R, Sharma J, Minhas SS, Mardi K. Hormone receptor status of breast cancer in the himalayan region of Northern India. Indian J Surg 2011;73(1):9–12. DOI: 10.1007/s12262-010-0121-5.
  23. Chariyalertsak S, Chariyalertsak S, Ruangvejvorachi P. Immunohistochemical detection of estrogen and progesterone receptors in primary breast cancer. Asian Pac J Allergy Immunol 1998;16(4):161–166.
  24. Lu X, Chen S, Huang S. A study on methodology and the criteria for positive immunohistostaining of estrogen and progesterone receptors in paraffin embedded sections of breast cancer. Zhonghua Bing Li Xue Za Zhi 1996;25(6):329–331.
  25. Li CI, Daling JR, Malone KE. Incidence of invasive breast cancer by hormone receptor status from 1992 to 1998. J Clin Oncol Off J Am Soc Clin Oncol 2003;21(1):28–34. DOI: 10.1200/JCO.2003.03.088.
  26. Hefti MM, Hu R, Knoblauch NW, Collins LC, Haibe-Kains B, Tamimi RM, et al. Estrogen receptor negative/progesterone receptor positive breast cancer is not a reproducible subtype. Breast Cancer Res [Internet] 2013;15(4). DOI: 10.1186/bcr3462Available from: http://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr3462.
  27. Dawood S, Broglio K, Buzdar AU, Hortobagyi GN, Giordano SH. Prognosis of women with metastatic breast cancer by HER2 status and trastuzumab treatment: an institutional-based review. J Clin Oncol 2010;28(1):92–98. DOI: 10.1200/JCO.2008.19.9844.
  28. Siddiqui B, Piyush AR, Faridi SH, Ahmad SS, Khan R. Trends in molecular classification of breast carcinoma in a tertiary health care centre: a 5 year retrospective study. Int Arch Biomed Clin Res 2016;2(2):69–72. DOI: 10.21276/iabcr.2016.2.2.15.
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