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VOLUME 9 , ISSUE 1 ( January-June, 2020 ) > List of Articles


COVID-19: Understanding the Enemy, the Battle Fought So Far, and the Battle Still to Wage!

Ranganadin Pajanivel, Rajagambeeram Reeta

Citation Information : Pajanivel R, Reeta R. COVID-19: Understanding the Enemy, the Battle Fought So Far, and the Battle Still to Wage!. 2020; 9 (1):7-11.

DOI: 10.5005/jp-journals-10085-8110

License: CC BY-NC 4.0

Published Online: 17-10-2020

Copyright Statement:  Copyright © 2020; The Author(s).


Together with the severe acute respiratory syndrome (SARS) coronavirus which threatened as pandemic in 2002–2003 and the MERS (Middle East respiratory syndrome) which was notified in 2012, the current and novel pathogen–novel coronavirus 2019 is the third highly pathogenic human coronavirus that has emerged in the last two decades and is exhibiting rapid survival tactics including transmissibility. Subsequent to its emergence, there has been an outpouring of information and data in the medical and nonmedical literature. The information is also so dynamic that the validity of information, especially the morbidity and mortality data become outdated everyday. This review aims at providing the overview about the agent and the epidemiological similarities and differences between the current novel coronavirus and the previous member of the family, the SARS-CoV and shared thoughts about what to be done further!

  1. Habibzadeh P, Stoneman EK. The novel coronavirus: a bird's eye view. Int J Occup Environ Med 2020;11(2):65–71. DOI: 10.15171/ijoem.2020.1921.
  2. Ashour HM, Elkhatib WF, Rahman MM, Elshabrawy HA. Insights into the recent 2019 novel coronavirus (SARS-CoV-2) in light of past human coronavirus outbreaks. Pathogens 2020;9(3):186. DOI: 10.3390/pathogens9030186.
  3. Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A novel coronavirus from patients with pneumonia in china, 2019. N Engl J Med 2020;82(8):727–733. DOI: 10.1056/NEJMoa2001017.
  4. Benvenuto D, Giovanetti M, Ciccozzi A, Spoto S, Angeletti S, Ciccozzi M. The 2019-new coronavirus epidemic: evidence for virus evolution. J Med Virol 2020;92(4):455–459. DOI: 10.1002/jmv.25688.
  5. Chan JF, Kok KH, Zhu Z, Chu H, To KK, Yuan S, et al. Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan. Emerg Microbes Infect 2020;9(1):221–236. DOI: 10.1080/22221751.2020.1719902.
  6. 2020.
  7. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, china. Lancet 2020;395(10223):497–506. DOI: 10.1016/S0140-6736(20)30183-5.
  8. Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, china: a descriptive study. Lancet 2020;395(10223):507–513. DOI: 10.1016/S0140-6736(20)30211-7.
  9. Chung M, Bernheim A, Mei X, Zhang N, Huang M, Zeng X, et al. CT imaging features of 2019 novel coronavirus (2019-nCoV). Radiology 2020;295(1):202–207. DOI: 10.1148/radiol.2020200230.
  10. Chen L, Liu HG, Liu W, Liu J, Liu K, Shang J, et al. Analysis of clinical features of 29 patients with 2019 novel coronavirus pneumonia. Zhonghua Jiehe He Huxi Zazhi 2020;43:E005.
  11. Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. J Am Med Assoc 2020;43:E005. DOI: 10.1001/jama.2020.1585.
  12. Kui L, Fang YY, Deng Y, Liu W, Wang MF, Ma JP, et al. Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province. Chin Med J (Engl) 2020;133(9):1025–1031. DOI: 10.1097/CM9.0000000000000744.
  13. Chang Lin M, Wei L, Xie L, Zhu G, Dela Cruz CS, et al. Epidemiologic and clinical characteristics of novel coronavirus infections involving 13 patients outside Wuhan, China. J Am Med Assoc 2020;323(11):1092–1093. DOI: 10.1001/jama.2020.1623.
  14. COVID-19 national incident room surveillance team. COVID-19. Australia: epidemiology report-2; 2020.
  15. Wang XF, Yuan J, Zheng YJ, Chen J, Bao YM, Wang YR, et al. Clinical and epi-demiological characteristics of 34 children with 2019 novel coronavirus infection in Shenzhen. Zhonghua Er Ke Za Zhi 2020;58:E008.
  16. Yang X, Yu Y, Xu J, Shu H, Xia J, Liu H, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med 2020;8(5):475–481. DOI: 10.1016/S2213-2600(20)30079-5.
  17. Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y, et al. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. N Engl J Med 2020;382(13):1199–1207. DOI: 10.1056/NEJMoa2001316.
  18. Wrapp D, Wang N, Corbett KS, Goldsmith JA, Hsieh CL, Abiona O, et al. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science 2020;367(6483):1260–1263. DOI: 10.1126/science.abb2507.
  19. China CDC weekly 2020;2:1-10.
  20. Holshue ML, DeBolt C, Lindquist S, Lofy KH, Wiesman J, Bruce H, et al. First case of 2019 novel coronavirus in the United states. N Engl J Med 2020;382(10):929–936. DOI: 10.1056/NEJMoa2001191.
  21. Zou L, Ruan F, Huang M, Liang L, Huang H, Hong Z, et al. SARS-CoV-2 viral load in upper respiratory specimens of infected patients. N Engl J Med 2020;382(12):1177–1179. DOI: 10.1056/NEJMc2001737.
  22. Pan F, Ye T, Sun P, Gui S, Li L, Zheng D, et al. Time course of lung changes on chest CT during recovery from 2019 novel coronavirus (COVID-19) pneumonia. Radiology 2020;295(3):715–721. DOI: 10.1148/radiol.2020200370.
  23. Wilder-Smith A, Chiew CJ, Lee VJ. Can we contain the COVID-19 outbreak with the same measures as for SARS? Lancet Infect Dis 2020;20:e102–e107. DOI: 10.1016/S1473-3099(20)30129-8.
  24. Wilder-Smith A, Freedman DO. Isolation, quarantine, social distancing and community containment: pivotal role for old-style public health measures in the novel coronavirus (2019-nCoV) outbreak. J Travel Med 2020;272(2):taaa020. DOI: 10.1093/jtm/taaa020.
  25. Cheng PK, Wong DA, Tong LK, Ip S-M, Lo ACT, Lau C-S, et al. Viral shedding patterns of coronavirus in patients with probable severe acute respiratory syndrome. Lancet 2004;363(9422):1699–1700. DOI: 10.1016/S0140-6736(04)16255-7.
  26. Goh KT, Cutter J, Heng BH, Ma S, Koh BKW, Kwok C, et al. Epidemiology and control of SARS in Singapore. Ann Acad Med Singapore 2006;35(5):301–316.
  27. Svoboda T, Henry B, Shulman L, Kennedy E, Rea E, Ng W, et al. Public health measures to control the spread of the severe acute respiratory syndrome during the outbreak in Toronto. N Engl J Med 2004;350(23):2352–2361. DOI: 10.1056/NEJMoa032111.
  28. Tsang T, Lam TH. SARS: public health measures in Hong Kong. Respirology 2003;8(Suppl):S46–S48.
  29. Ahmad A, Krumkamp R, Reintjes R. Controlling SARS: a review on china's response compared with other SARS-affected countries. Trop Med Int Health 2009;14(Suppl 1):36–45. DOI: 10.1111/j.1365-3156.2008.02146.x.
  30. Leung GM, Quah S, Ho LM, Ho SY, Hedley AJ, Lee HP, et al. A tale of two cities: community psycho behavioral surveillance and related impact on outbreak control in Hong Kong and Singapore during the severe acute respiratory syndrome epidemic. Infect Control Hosp Epidemiol 2004;25:1033–1041. DOI: 10.1086/502340.
  31. Leung GM, Hedley AJ, Ho LM, Chau P, Wong IOL, Thach TQ, et al. The epidemiology of severe acute respiratory syndrome in the 2003 Hong Kong epidemic: an analysis of all 1755 patients. Ann Intern Med 2004;141(9):662–673. DOI: 10.7326/0003-4819-141-9-200411020-00006.
  32. Wilder-Smith A. The severe acute respiratory syndrome: impact on travel and tourism. Travel Med Infect Dis 2006;4(2):53–60. DOI: 10.1016/j.tmaid.2005.04.004.
  33. McCloskey B, Heymann DL. SARS to novel coronavirus—old lessons and new lessons. Epidemiol Infect 2020;148:e22. DOI: 10.1017/S0950268820000254.
  34. Wang C, Horby PW, Hayden FG, Gao GF. A novel coronavirus outbreak of global health concern. Lancet 2020;395(10223):470–473. DOI: 10.1016/S0140-6736(20)30185-9.
  35. Nkengasong J. China's response to a novel coronavirus stands in stark contrast to the 2002 SARS outbreak response. Nat Med 2020;26(3):310–311. DOI: 10.1038/s41591-020-0771-1.
  36. Gates B. Responding to COVID-19—A once-in-a-century pandemic? N Engl J Med 2020;382(18):1677–1679. DOI: 10.1056/NEJMp2003762.
  37. Gates B. Innovation for pandemics. N Engl J Med 2018;378(22): 2057–2060. DOI: 10.1056/NEJMp1806283.
  38. Frieden TR, Tappero JW, Dowell SF, Hien NT, Guillaume FD, Aceng JR. Safer countries through global health security. Lancet 2014;383(9919):764–766. DOI: 10.1016/S0140-6736(14) 60189-6.
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