Background: Diabetes is a life-changing disease associated with the severe morbidity and also mortality. Among the diabetic patients, the prevalence of foot ulcers will usually be as high as 20%. These ulcers usually become infected, cause very high morbidity, and are the usual first step for lower extremity amputation. The holistic care of diabetic foot ulcers requires a multidisciplinary approach. Apart from blood sugar control, treatment of ulcer involves wound debridement, appropriate dressings, vascular maintenance, and control of infections. The most important factor in preventing amputation is a repeated education of the patient in foot care and to really look into factors associated with amputation. This review article is an attempt to identify the statistically significant risk factors leading to lower extremity amputation. Materials and methods: The research literature was searched for various studies reporting the risk factors for lower extremity amputation in patients with DFI. A systematic search of literature was conducted first in MEDLINE/PubMed and then in Cochrane Central Register of Controlled Trials till July 2019. This search retrieved 11 most relevant articles. The risk factors that led to LEA were studied and data were analyzed. Results: Based on the comparison, we have concluded that male preponderance, duration of diabetes, and vasculopathy were found to be statistically significant in majority of the studies.