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VOLUME 8 , ISSUE 1 ( January-June, 2019 ) > List of Articles


Bedaquiline: A Mini Review

Nandhini Saravanabavan, Padmavathi Shanmuganathan, Manimekalai Kumarappan

Keywords : Antitubercular drug, Bedaquiline, Multidrug-resistant tuberculosis

Citation Information : Saravanabavan N, Shanmuganathan P, Kumarappan M. Bedaquiline: A Mini Review. 2019; 8 (1):2-4.

DOI: 10.5005/jp-journals-10085-8101

License: CC BY-NC 4.0

Published Online: 08-08-2020

Copyright Statement:  Copyright © 2019; The Author(s).


Tuberculosis is a pandemic, chronic infectious disease which affects more than 10 million people in the world. About 3.5% of patients of newly diagnosed have reported having multidrug-resistant tuberculosis (MDR-TB). The standard treatment of MDR-TB has many cons like high cost, less effectiveness, and more drug interactions. Thus, to overcome these disadvantages a new novel compound which belongs to the diarylquinolone group called bedaquiline has been developed as a part of combination therapy in adults with MDR-TB for its bactericidal activity. It mainly acts by inhibiting the adenosine triphosphate synthase enzyme of Mycobacterium tuberculosis. This drug was introduced as a new addition to the standard TB regimen after 50 years.

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