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VOLUME 8 , ISSUE 1 ( January-June, 2019 ) > List of Articles


Topical Application of Mitomycin C in Functional Endoscopic Sinus Surgery

Roby T Koshy, Surianarayanan Gopalakrishnan, P Karthikeyan

Keywords : Endoscopic sinus surgery, Mitomycin C, Triamcinolone acetonide

Citation Information : Koshy RT, Gopalakrishnan S, Karthikeyan P. Topical Application of Mitomycin C in Functional Endoscopic Sinus Surgery. 2019; 8 (1):19-22.

DOI: 10.5005/jp-journals-10085-8106

License: CC BY-NC 4.0

Published Online: 08-08-2020

Copyright Statement:  Copyright © 2019; The Author(s).


Background: Functional endoscopic sinus surgery (FESS) is the surgical management of choice for chronic rhinosinusitis (CRS). However, the results do not give optimal results due to the development of synechiae, which results in recurrence of the sinusitis. Intraoperative use of mitomycin C (MMC) reduces the incidence of postoperative development of synechiae in patients undergoing FESS. This review attempts to provide a brief overview for application of MMC during FESS. Materials and methods: In this article, we reviewed various randomized, clinical, and experimental trials conducted between 1990 and 2015 and which were published in various Indian and American journals. Literature search was conducted after using the key words endoscopic sinus surgery (ESS), triamcinolone acetonide, and MMC from Pubmed, Cochrane, Proquest, and Google Scholar. Conclusion: The topical use of MMC and triamcinolone acetonide was comparable in reducing the formation of synechiae and crusts in the postoperative period and thereby improving the outcome.

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