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VOLUME 11 , ISSUE 2 ( July-December, 2022 ) > List of Articles

REVIEW ARTICLE

Are Phenotypes of PCOS and Vitamin D Levels Interlinked

Karri Lakshmi Manasa, Mangaiyarkarasi Ravirajan

Keywords : Phenotypes of polycystic ovarian syndrome, Polycystic ovarian syndrome, Vitamin D

Citation Information : Manasa KL, Ravirajan M. Are Phenotypes of PCOS and Vitamin D Levels Interlinked. 2022; 11 (2):33-35.

DOI: 10.5005/jp-journals-10085-9101

License: CC BY-NC 4.0

Published Online: 31-12-2022

Copyright Statement:  Copyright © 2022; The Author(s).


Abstract

Aim: The present review is done to analyze the serum vitamin D levels in different phenotypes of polycystic ovarian syndrome (PCOS). Objectives: To estimate the serum levels of vitamin D in women with PCOS and without PCOS. To find out the distribution of different phenotypes of PCOS. To compare the serum vitamin D levels in different phenotypes of PCOS. Background: Polycystic ovarian syndrome is the most common heterogeneous multisystem endocrinopathy in women of reproductive age. It is further divided into four phenotypes based on Rotterdam criteria. Vitamin D levels are known to be low among women with PCOS. Only limited literature is available related to vitamin D deficiency and the phenotypes of PCOS. This review has highlighted the phenotypes of PCOS and their correlation with vitamin D levels. Methods: An electronic search strategy was used to select the studies from different databases like PubMed, Google Scholar, SciELO, and ResearchGate. A combination of keywords like vitamin D, PCOS, and phenotypes of PCOS were used to select the studies. Inclusion criteria were studies in English, duration of search of 18 months, case–control studies and cross-sectional studies only. Results: Phenotype A was the most frequently found phenotype among the different phenotypes of PCOS. After analyzing the data, there was a positive association between vitamin D and PCOS. Obese women were more prone to have vitamin D deficiency. Women with vitamin D deficiency were found to have ovarian dysfunction and insulin resistance. But there was no strong consensus on the association between vitamin D and phenotypes of PCOS. Conclusion: We found a statistically significant difference in mean serum vitamin D levels among the women with PCOS and without PCOS. The most common phenotype was phenotype A and the least common was phenotype D. There was no significant difference in serum vitamin D levels in respect to different phenotypes of PCOS. Further studies with larger sample size in each phenotype are recommended to conclusively establish the variation of serum vitamin D level in PCOS, particularly related to phenotypes. Clinical significance: Vitamin D supplementation was found to be beneficial for women with PCOS.

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  1. Azziz R, Carmina E, Dewailly D, Diamanti-Kandarakis E, Escobar-Morreale HF, Futterweit W, et al. The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report. Fertil Steril 2009;91(2):456–488. DOI: 10.1016/j.fertnstert.2008.06.035.
  2. Wehr E, Pilz S, Schweighofer N, Giuliani A, Kopera D, Pieber TR, et al. Association of hypovitaminosis D with metabolic disturbances in polycystic ovary syndrome. Eur J Endocrinol 2009;161(4):575–582. DOI: 10.1530/EJE-09-0432.
  3. Sachdeva G, Gainder S, Suri V, Sachdeva N, Chopra S. Comparison of the different PCOS phenotypes based on clinical metabolic, and hormonal profile, and their response to clomiphene. Indian J Endocrinol Metab 2019;23(3):326. DOI: 10.4103/ijem.IJEM_30_19.
  4. Zhang H, Zhu F, Xiong J, Shi X, Fu S. Characteristics of different phenotypes of polycystic ovary syndrome based on the Rotterdam criteria in a large-scale Chinese population: characteristics of different polycystic ovary syndrome phenotypes. BJOG Int J Obstet Gynaecol 2009;116(12):1633–1639. DOI: 10.1111/j.1471-0528.2009.02347.x.
  5. Diamanti Kandarakis E, Panidis D. Unravelling the phenotypic map of polycystic ovary syndrome (PCOS): a prospective study of 634 women with PCOS. Clin Endocrinol (Oxf) 2007;67(5):735–742. DOI: 10.1111/j.1365-2265.2007.02954.x.
  6. Pehlivanov B, Orbetzova M. Characteristics of different phenotypes of polycystic ovary syndrome in a Bulgarian population. Gynecol Endocrinol Off J Int Soc Gynecol Endocrinol 2007;23(10):604–609. DOI: 10.1080/09513590701536246.
  7. Clark NM, Podolski AJ, Brooks ED, Chizen DR, Pierson RA, Lehotay DC, et al. Prevalence of polycystic ovary syndrome phenotypes using updated criteria for polycystic ovarian morphology. Reprod Sci 2014;21(8):1034–1043. DOI: 10.1177/1933719114522525.
  8. Kayaniyil S, Vieth R, Retnakaran R, Knight JA, Qi Y, Gerstein HC, et al. Association of vitamin D with insulin resistance and β-cell dysfunction in subjects at risk for type 2 diabetes. Diabetes Care 2010;33(6):1379–1381. DOI: 10.2337/dc09-2321.
  9. Kim JJ, Choi YM, Chae SJ, Hwang KR, Yoon SH, Kim MJ, et al. Vitamin D deficiency in women with polycystic ovary syndrome. Clin Exp Reprod Med 2014;41(2):80–85. DOI: 10.5653/cerm.2014.41.2.80.
  10. Jedrzejuk D, Łaczmański Ł, Milewicz A, Kuliczkowska-Płaksej J, Lenarcik-Kabza A, Hirnle L, et al. Classic PCOS phenotype is not associated with deficiency of endogenous vitamin D and VDR gene polymorphisms rs731236 (TaqI), rs7975232 (ApaI), rs1544410 (BsmI), rs10735810 (FokI): a case–control study of lower Silesian women. Gynecol Endocrinol 2015;31(12):976–979. DOI: 10.3109/09513590.2015.1062865.
  11. Jia XZ, Wang Y-M, Zhang N, Guo L-N, Zhen X-L, Li H, et al. Effect of vitamin D on clinical and biochemical parameters in polycystic ovary syndrome women: A meta-analysis. J Obstet Gynaecol Res 2015;41(11):1791–1802. DOI: 10.1111/jog.12793.
  12. He C, Lin Z, Robb SW, Ezeamama AE. Serum vitamin D levels and polycystic ovary syndrome: a systematic review and meta-analysis. Nutrients 2015;7(6):4555–4577. DOI: 10.3390/nu7064555.
  13. Sidabutar E, Halim B, Siregar MFG, Lutan D, Adenin I, Kaban Y. Vitamin D levels in women with polycystic ovary syndrome. KnE Med 2016;1(1):125–132. DOI: 10.18502/kme.v1i1.547.
  14. Maktabi M, Chamani M, Asemi Z. The effects of vitamin D supplementation on metabolic status of patients with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Horm Metab Res 2017;49(7):493–498. DOI: 10.1055/s-0043-107242.
  15. Krul Poel YHM, Koenders PP, Steegers-Theunissen RP, Boekel E ten, Wee MM ter, Louwers Y, et al. Vitamin D and metabolic disturbances in polycystic ovary syndrome (PCOS): a cross-sectional study. PLoS One 2018;13(12). DOI: 10.1371/journal.pone.0204748.
  16. Jukic AMZ, Wilcox AJ, McConnaughey DR, Weinberg CR, Steiner AZ. 25-hydroxyvitamin D and long menstrual cycles in a prospective cohort study. Epidemiol Camb Mass 2018;29(3):388–396. DOI: 10.1097/EDE.0000000000000804.
  17. Shah S, Ramadevi. Case control study of serum vitamin D levels in PCOS patients. Int J Sci Res 2018;17(8):16–22. DOI: 10.9790/0853-1708061622.
  18. Hahn S, Haselhorst U, Tan S, Quadbeck B, Schmidt M, Roesler S, et al. Low serum 25-hydroxyvitamin D concentrations are associated with insulin resistance and obesity in women with polycystic ovary syndrome. Exp Clin Endocrinol Diabetes Off J Ger Soc Endocrinol Ger Diabetes Assoc 2006;114(10):577–583. DOI: 10.1055/s-2006-948308.
  19. Elkholy SSh, Mostafa RA, Riad AA. Assessment of vitamin D levels in women with polycystic ovarian syndrome. Egypt J Hosp Med 2018;70(4):594–600. DOI: 10.12816/0043811.
  20. Davis EM, Peck JD, Hansen KR, Neas BR, Craig LB. Associations between vitamin D levels and polycystic ovary syndrome (PCOS) phenotypes. Minerva Endocrinol 2018;44(2):176–184. DOI: 10.23736/S0391-1977.18.02824-9.
  21. Eftekhar M, Mirashemi ES, Molaei B, Pourmasumi S. Is there any association between vitamin D levels and polycystic ovary syndrome (PCOS) phenotypes? 2020;64(1):11–16. DOI: 10.20945/2359-3997000000177.
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