In this article the role of herbs in Tuberculosis have been compiled based on their availability as commonly used household remedies such as spices, condiments, fruits, vegetables, flowers etc and other herbs based on their effectiveness in inhibiting Mycobacterium. tuberculosis both normal or multidrug resistant strains or their ability to prevent anti tuberculous drug induced adverse effects such as hepatotoxicity. The herbs or formulations which have relevance to tuberculosis andscientifically evaluated invitro or invivo in animal models or in clinical studies and found to have positive effects have been included in this compilation.
Animal models help us to understand and explore disease mechanisms. Every disease causing organism has its own evolving genome and interacting ways with the environment, which demands new animal models for studying them. Versatile and cost effective disease models are always in demand for drug discovery. Laboratory mouse and rat animal models, though well appreciated in the fields of drug discovery and basic science research is getting replaced with the disease models of Zebrafish as they are easy to breed, hold and discard. Cost effectiveness and the less implied Animal ethics regulations have made researchers in the West to shift to this model. Although Zebrafish models on various diseases are available, tuberculosis disease model is discussed here for the benefit of researchers interested or involved in anti-tuberculosis drug discovery.
Dr. Prof Vishwanath R Hiremath,
Dr. Pranjali Kurhekar,
Dr. Dilip Kumar,
Dr. T Krishna Prasad.
Tuberculosis (TB) remains one of the major occupational risk hazards for anaesthesiologist and health care workers in operation rooms in some of the developing countries. Anaesthesiologists do come across providing anaesthesia for patients with active tuberculosis or problems unrelated to tuberculosis like trauma and for various surgeries. As per the World Health Organization (WHO) reporting in 2013, 9 million new cases are supposed to be suffering from TB; among this 2-3% cases are found to be drug resistant. It is true that effective infection control measures and the availability of effective antibiotics for mycobacterium tuberculosis have decreased the risk of nosocomial infection. However, anaesthesiologist and the health workers in the developing countries are still at the risk of tuberculosis transmission from the patients when compared to their counterparts in the developed countries; due to the lack of adequate resources to prevent nosocomial transmission of tuberculosis. Hence, the special precautions need to be under taken by the anaesthesiologist while providing anaesthesia to these patients. From the patient point of view various drug interactions, side effects of anti-tuberculosis drugs needs to be considered preoperatively along with necessary investigations. Immune compromised patients with co infected HIV have a higher risk of developing tuberculosis.
Dr. R V Sridhar,
Dr. S Senthil Kumar,
Dr. G Srividhya
Tuberculosis of breast is rare in the west. It is rare even in developing countries where the incidence of Extra Pulmonary Tuberculosis is high. Kancheepuram District in Tamilnadu is known for its endemicity in Tuberculosis. Tuberculosis of breast occurring in young female which is a rare site for Extra Pulmonary Tuberculosis is presented here.